Medication-related osteonecrosis of the jaw occurs MOST commonly in which site?

Correct answer: D. Posterior mandible

• A. ❌ Maxillary lesions account for roughly a quarter to a third of cases.
• B. ❌ The anterior maxilla is the least common site of all.
• C. ❌ The anterior mandible is affected far less often, though tori and the mylohyoid ridge are recognized sites.
• D. ✅ CORRECT — Roughly two-thirds of MRONJ cases occur in the MANDIBLE, most often in the POSTERIOR region — particularly the mylohyoid ridge and lingual plate. The mandible's denser cortical bone and comparatively limited collateral blood supply, combined with thin overlying mucosa in these areas, explain the predilection.

Note: Staging is based on exposed bone, symptoms and infection. Prevention beats treatment: complete invasive dentistry BEFORE antiresorptive therapy begins where possible.