Medical Emergencies · single question
Janeway lesions on the hands and feet are associated with which disease?
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Correct answer: A. Infective endocarditis
- A. JANEWAY LESIONS are painless, irregular ERYTHEMATOUS macules on the PALMS and SOLES — they are one of the peripheral manifestations of INFECTIVE ENDOCARDITIS. They result from septic emboli depositing in the peripheral vasculature. Other cardiac embolic phenomena: Osler's nodes (painful, finger/toe tips — immune complex), Roth spots (retinal hemorrhages), subungual splinter hemorrhages.
- B. Sjögren's causes dry eyes and dry mouth (sicca symptoms) — not Janeway lesions.
- C. Pulmonary embolism causes lung infarction — NOT Janeway lesions. Janeway lesions are specific to infective endocarditis.
- D. RA causes joint deformities and subcutaneous nodules — not Janeway lesions.
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