In the same patient with nicotinic stomatitis who is also found to have a concurrent wipeable white plaque from pseudomembranous candidiasis under the denture, what is the appropriate antifungal treatment?

For denture-related candidiasis (denture stomatitis) associated with a removable denture, nystatin oral suspension is a standard topical antifungal treatment. The suspension can be applied directly to both the oral mucosa and the fitting surface of the denture. Nystatin is a polyene antifungal that binds to ergosterol in the fungal cell membrane, creating pores that lead to cell lysis. Crucially, the denture itself must also be treated (soaked in antifungal solution or dilute chlorhexidine overnight) and worn only during the day, as the denture acts as a reservoir for Candida. Clotrimazole troches are also effective for oral candidiasis. The note in the original explanation that 'nicotinic stomatitis itself may not require antifungal treatment' is correct — the antifungal addresses the coexisting candidiasis.