In the management of sickle cell anemia, which intervention helps IMPROVE (decrease severity of) sickle cell crises?

Hydroxyurea increases fetal hemoglobin (HbF), which does not polymerize with HbS. This reduces the proportion of HbS available to sickle, decreasing the frequency and severity of painful crises, acute chest syndrome, and need for transfusions. Maintaining adequate hydration is also critical. Dehydration worsens sickling by concentrating HbS.