Pathology · single question

In a patient with Sjögren's syndrome, what would a labial (lip) minor salivary gland biopsy classically show?

  1. Focal lymphocytic infiltration (immune cell infiltrate) around the minor salivary gland acini and ducts
  2. Predominantly fat cell (adipose) replacement of glandular tissue
  3. Normal, unremarkable glandular architecture
  4. Granulomatous inflammation
Show answer and explanation

Correct answer: A. Focal lymphocytic infiltration (immune cell infiltrate) around the minor salivary gland acini and ducts

The labial minor salivary gland biopsy is a standard diagnostic test for Sjögren's syndrome, classically showing focal lymphocytic sialadenitis — a focal infiltration of lymphocytes (immune cells) around the salivary gland acini and ducts, scored using a focus score to support the diagnosis.

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