Implants · single question
How does diabetes mellitus affect peri-implantitis/implant outcomes?
Show answer and explanation
Correct answer: A. Inhibits osteoblast activity
✓ A) Inhibits osteoblast activity is correct.
In poorly controlled diabetes, hyperglycemia impairs osteoblast function, reducing bone formation and osseointegration. Additionally, diabetes causes increased inflammatory mediators (TNF-α, IL-1β), impaired neutrophil function, microangiopathy (reduced blood supply), and delayed wound healing. This collectively leads to reduced osseointegration, higher peri-implantitis rates, and increased implant failure in uncontrolled diabetics. Well-controlled diabetics (HbA1c <7%) have implant success rates similar to non-diabetics.
In poorly controlled diabetes, hyperglycemia impairs osteoblast function, reducing bone formation and osseointegration. Additionally, diabetes causes increased inflammatory mediators (TNF-α, IL-1β), impaired neutrophil function, microangiopathy (reduced blood supply), and delayed wound healing. This collectively leads to reduced osseointegration, higher peri-implantitis rates, and increased implant failure in uncontrolled diabetics. Well-controlled diabetics (HbA1c <7%) have implant success rates similar to non-diabetics.