For managing mild-to-moderate acute dental pain in a healthy adult patient, which analgesic combination is most evidence-based and effective?

The combination of acetaminophen (650–1000 mg) and ibuprofen (400–600 mg) taken together is the most effective evidence-based regimen for acute dental pain and is superior to opioid-containing combinations for dental pain in studies. This combination works by dual mechanisms — acetaminophen acts centrally, while ibuprofen provides peripheral anti-inflammatory and analgesic effects through COX inhibition. This regimen avoids the risks of opioid dependence, sedation, and constipation. Opioids are reserved for severe pain not responsive to non-opioid therapy.