Pharmacology · single question
For a patient with HIV on antiretroviral therapy, which option for anxiety/sedation is safe to provide?
Show answer and explanation
Correct answer: A. Nitrous oxide-oxygen sedation
- A. Correct. Nitrous oxide is safe and has no significant interaction with antiretrovirals.
- B. Triazolam is a CYP3A4 substrate; protease inhibitors/ritonavir inhibit CYP3A4 and can cause dangerous oversedation, so it is best avoided.
- C. Azole antifungals are also strong CYP3A4 inhibitors and not a sedation choice.
- D. Withholding all care is neither necessary nor appropriate.