Excessive zinc content in certain denture adhesive creams has been linked to which serious complication with prolonged, heavy use?

Excessive, prolonged use of zinc-containing denture adhesive creams has been documented (in case reports and an FDA safety communication) to cause zinc-induced copper deficiency, which can lead to myeloneuropathy (peripheral neuropathy) and bone marrow suppression — a recognized, if uncommon, complication that led some manufacturers to reformulate or relabel their products.