Ectodermal dysplasia — what is one of the major distinguishing features?

Correct answer: A. Heat intolerance (inability to sweat)

• A. ✅ Correct. Heat intolerance is a hallmark of ectodermal dysplasia. Absent/reduced eccrine sweat glands prevent effective thermoregulation, causing potentially life-threatening hyperthermia, especially in infants.
• B. ❌ Hepatomegaly has no association with ectodermal dysplasia.
• C. ❌ Facial clefts are associated with Van der Woude syndrome and Pierre Robin.
• D. ❌ Microcephaly is associated with various chromosomal/teratogenic conditions.

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