Pathology · single question

Each of the following is a risk factor for Tetralogy of Fallot EXCEPT:

  1. Alcohol consumption (in pregnancy)
  2. Iron deficiency
  3. Maternal folic acid supplementation
  4. Smoking (in pregnancy)
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Correct answer: C. Maternal folic acid supplementation

Maternal alcohol use, smoking, and certain nutritional deficiencies are linked to increased risk of congenital heart defects including Tetralogy of Fallot. Folic acid SUPPLEMENTATION, however, is protective against many congenital anomalies (including some congenital heart defects) — it is not a risk factor, making it the exception (a folic acid DEFICIENCY, not supplementation, would be the risk factor).

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