Pathology · single question

Demyelination of which cell type's myelin sheaths is the underlying pathology in multiple sclerosis, a disease of autoimmune origin?

  1. Schwann cells
  2. Oligodendrocytes
  3. Astrocytes
  4. Microglia
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Correct answer: B. Oligodendrocytes

Oligodendrocytes produce and maintain myelin in the central nervous system, and their autoimmune-mediated destruction is the central pathology of multiple sclerosis. Schwann cells perform the analogous function in the peripheral nervous system (relevant to conditions like Guillain-Barré syndrome instead).

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