Anatomy & Histology · single question
Collagen FIBERS (not the matrix) begin forming at what time point after wound healing begins?
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Correct answer: A. 4 to 5 days
- A. Correct. Organized collagen FIBERS begin forming at approximately 4–5 DAYS after wounding. This is when fibroblasts begin laying down type III collagen (later remodeled to type I). Tensile strength increases significantly from days 4–5 onward.
- B. Incorrect. 2 days = 48 hours; same as option A — fibroblast migration is beginning but organized fibers have not yet formed.
- C. Incorrect. At 2 weeks, collagen fibers are well-established and remodeling is underway — this is beyond initial fiber formation.
- D. Incorrect. At 48 hours, fibroblasts are beginning to migrate and proliferate — collagen MATRIX (ground substance) begins forming, but organized FIBERS have not yet appeared.
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