Medical Emergencies · single question

CASE — Multiple myeloma. Bence Jones proteins (monoclonal free light chains) are classically detected in which specimen?

  1. A peripheral blood smear
  2. Urine
  3. Saliva
  4. Cerebrospinal fluid
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Correct answer: B. Urine

  • A. A blood smear shows cell morphology (e.g., rouleaux), not Bence Jones proteins directly.
  • B. Correct. Bence Jones proteins are free light chains found in the URINE (urine protein electrophoresis).
  • C. Saliva is not the diagnostic specimen for Bence Jones protein.
  • D. CSF is not used to detect Bence Jones protein.

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