Pharmacology · single question
Capsaicin produces analgesia by depleting which neuropeptide from sensory nerve endings?
Show answer and explanation
Correct answer: A. Substance P
- A. Correct. Capsaicin activates TRPV1 receptors and, with repeated use, depletes substance P from afferent nociceptive neurons, reducing pain transmission.
- B. Acetylcholine is not the target of capsaicin's analgesic depletion.
- C. Dopamine is a CNS neurotransmitter unrelated to capsaicin's peripheral mechanism.
- D. GABA is an inhibitory neurotransmitter, not depleted by capsaicin.