Micro & Immunology · single question

All of the following organisms are intrinsically resistant to clindamycin EXCEPT:

  1. Pseudomonas aeruginosa
  2. Streptococcus viridans
  3. Staphylococcus aureus (MRSA with inducible resistance)
  4. Enterococcus species
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Correct answer: B. Streptococcus viridans

Clindamycin is effective against many gram-positive cocci and anaerobes. Streptococcus viridans (viridans group streptococci) are generally susceptible to clindamycin and this is why clindamycin is an alternative to amoxicillin for endocarditis prophylaxis in penicillin-allergic patients. Pseudomonas aeruginosa is intrinsically resistant to clindamycin (gram-negative rod with outer membrane barrier). MRSA can have inducible clindamycin resistance (D-zone test detects this). Enterococcus species are intrinsically resistant to clindamycin. Clindamycin's spectrum covers gram-positive organisms (streptococci, staphylococci) and anaerobes, but NOT Pseudomonas or Enterococcus.

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