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Infection Control · single question

After a needlestick injury, what is the maximum recommended time window to initiate Hepatitis B post-exposure prophylaxis (PEP)?

  1. Within 14 days
  2. Within 7 days
  3. Within 48–72 hours
  4. Within 24 hours
Show answer and explanation

Correct answer: B. Within 7 days

  • A. INCORRECT — 14 days is the outer limit for sexual exposures, not percutaneous needlestick injuries.
  • B. CORRECT — Per current clinical guidelines, HBV PEP (HBIG + vaccine) should be given as soon as possible but remains effective for percutaneous exposures up to 7 days. Sooner is always better; within 24 hours is ideal.
  • C. INCORRECT — 48–72 hours is a commonly cited practical window, but HBIG may remain effective up to 7 days after percutaneous exposure per current NCCC/CDC guidelines.
  • D. INCORRECT — While 24 hours is the ideal window for maximum effectiveness, HBV PEP (HBIG + vaccine) is still recommended up to 7 days post-exposure for percutaneous needlestick injuries.

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