Pathology · single question

A 'Swiss cheese' (cribriform) histologic pattern is most classically associated with which salivary gland tumor?

  1. Adenoid cystic carcinoma
  2. Mucoepidermoid carcinoma
  3. Pleomorphic adenoma
  4. Warthin tumor
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Correct answer: A. Adenoid cystic carcinoma

Adenoid cystic carcinoma classically shows a cribriform ('Swiss cheese') growth pattern on histology, along with a notorious tendency for perineural invasion, which contributes to its high rate of local recurrence and a generally poor long-term prognosis despite a relatively slow growth pattern. Mucoepidermoid carcinoma instead shows a mix of mucous, epidermoid, and intermediate cells.

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