Pathology · single question

A radiolucent lesion is found between teeth #13 and #14. Which of the following should be EXCLUDED from the differential diagnosis?

  1. Traumatic bone cyst
  2. Odontogenic Keratocyst (OKC)
  3. Ameloblastoma
  4. Lateral periodontal cyst
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Correct answer: C. Ameloblastoma

Ameloblastoma is classically found in the posterior mandible (especially around the third molar and ramus area) and is extremely rare in the maxilla. A radiolucent lesion between the maxillary premolars (#13–#14) would more likely represent OKC, lateral periodontal cyst, or traumatic bone cyst. Ameloblastoma should be excluded from this location.
  • A. Traumatic bone cysts can appear in the premolar–molar region and are a valid differential for radiolucent jaw lesions at this location.
  • B. OKC can occur anywhere in the jaws and is a valid differential for a radiolucent lesion between #13 and #14.
  • C. CORRECT (EXCLUDED). Ameloblastoma is overwhelmingly found in the posterior mandible. A maxillary premolar interproximal radiolucent lesion would not have ameloblastoma as a likely differential — it should be excluded.
  • D. Lateral periodontal cysts classically occur in the premolar region of both jaws and are a valid differential for an interproximal radiolucency at this location.

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