Radiology · single question
A radiograph shows a missing tooth with a SMALL ODONTOMA in that area. What syndrome is most likely?
Show answer and explanation
Correct answer: B. Gardner's Syndrome (odontoma + osteoma + intestinal polyps + epidermoid cysts)
✓ B) Gardner's Syndrome is correct when odontomas + missing/impacted teeth are found.
Gardner's Syndrome (FAP — familial adenomatous polyposis): APC gene (autosomal dominant). Features: (1) ODONTOMAS (hypercementosis, supernumerary teeth, impacted teeth); (2) Osteomas (jaw, skull, long bones); (3) Intestinal polyps (100% colon cancer risk); (4) Epidermoid cysts (skin); (5) Desmoid tumors. KEY: Gardner = odontoma + osteoma + colonic polyposis. OKCs → Gorlin. Dentigerous cysts + supernumeraries → Cleidocranial dysplasia (NOTE: dentigerous cysts in CCD, not odontomas). Odontoma in a missing tooth area = Gardner's.
Gardner's Syndrome (FAP — familial adenomatous polyposis): APC gene (autosomal dominant). Features: (1) ODONTOMAS (hypercementosis, supernumerary teeth, impacted teeth); (2) Osteomas (jaw, skull, long bones); (3) Intestinal polyps (100% colon cancer risk); (4) Epidermoid cysts (skin); (5) Desmoid tumors. KEY: Gardner = odontoma + osteoma + colonic polyposis. OKCs → Gorlin. Dentigerous cysts + supernumeraries → Cleidocranial dysplasia (NOTE: dentigerous cysts in CCD, not odontomas). Odontoma in a missing tooth area = Gardner's.