Pathology · single question

A picture shows a white lesion on the floor of the mouth — very white, spongy-appearing, non-ulcerated. What is the MOST likely diagnosis?

  1. Squamous Cell Carcinoma (SCC)
  2. White Sponge Nevus
  3. Candidiasis (thrush)
  4. Leukoplakia
Show answer and explanation

Correct answer: B. White Sponge Nevus

White Sponge Nevus (WSN) presents as bilateral, symmetric, folded/spongy white plaques on the buccal mucosa and floor of mouth. It is benign, autosomal dominant, caused by mutations in keratin 4 or 13, and is non-ulcerated. The key distinguishing feature is the 'spongy' white appearance without induration. SCC would present with induration, ulceration, or fixation. Candidiasis is typically wiped off. Leukoplakia is flat, not spongy.

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