Biostatistics & Research · single question

A PICO study asks about fluoride varnish — what does the 'I' in PICO represent?

  1. Intervention
  2. Incisors
  3. Incidence
  4. Indication
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Correct answer: A. Intervention

  • A. PICO is the clinical research framework: P = Patient/Problem/Population, I = INTERVENTION (the treatment/exposure being studied), C = Comparison (control group), O = Outcome. In a study about fluoride varnish, the INTERVENTION (I) is FLUORIDE VARNISH — it is the treatment being evaluated.
  • B. Incisors might be the population in a dental study — but 'I' in PICO always = INTERVENTION.
  • C. Incidence is a statistical measure — it is NOT what 'I' stands for in PICO.
  • D. Indication is the clinical indication for a treatment — not the PICO 'I'.

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