Infection Control · single question
A patient who has been VACCINATED against Hepatitis B (immune, never infected) shows which serology?
Show answer and explanation
Correct answer: A. Anti-HBs positive (HBsAg negative, anti-HBc negative)
- A. Correct. Vaccination produces isolated anti-HBs (surface antibody) positivity, with HBsAg and anti-HBc (core antibody) negative — indicating immunity without prior infection.
- B. Incorrect. HBsAg (surface antigen) positivity indicates active infection, not vaccination.
- C. Incorrect. Anti-HBc (core antibody) indicates natural infection/exposure; it is NOT produced by the vaccine.
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