Radiology · single question
A patient presents with no erupted teeth, but a radiographic examination reveals supernumerary teeth. Which syndrome is most commonly associated with this finding?
Show answer and explanation
Correct answer: B. Cleidocranial dysplasia
Cleidocranial dysplasia is a genetic condition characterized by delayed eruption of teeth, multiple supernumerary teeth, and hypoplastic or absent clavicles. It is caused by mutations in the RUNX2 gene, which plays a role in bone and dental development. Radiographs of affected individuals often reveal unerupted permanent teeth and numerous supernumerary teeth, which can impede normal tooth eruption. On the other hand: Ectodermal dysplasia is associated with missing teeth (hypodontia) and abnormalities of other ectodermal tissues but does not typically involve supernumerary teeth. Mandibulofacial dysostosis (Treacher Collins syndrome) is more related to craniofacial deformities without characteristic findings of supernumerary teeth. Amelogenesis imperfecta affects enamel formation but is not linked to supernumerary teeth or delayed eruption.