Pathology · single question
A patient presents with a small, soft, exophytic, cauliflower-like lesion on the soft palate that has a rough, white surface and has been slowly growing for six months. It is caused by human papillomavirus (HPV). What is the most likely diagnosis?
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Correct answer: A. Squamous papilloma
Squamous papilloma is the most common benign epithelial neoplasm of the oral cavity, caused primarily by HPV subtypes 6 and 11. It presents as a pedunculated or sessile, exophytic, soft lesion with finger-like projections giving it a cauliflower or warty appearance. Common locations include the soft palate, uvula, tongue, and lips. Treatment is conservative surgical excision with a small margin of normal tissue. Recurrence is uncommon. Verruca vulgaris (common wart) is caused by HPV 2 and 4, typically on skin but can occur in the mouth. Pyogenic granuloma is a vascular lesion. Fibroma is a fibrous reactive lesion without HPV etiology.