Prosthodontics & Occlusion · single question

A patient on oral bisphosphonate therapy (alendronate) for 2 years requests full-mouth extractions to be fitted for complete dentures. What is the most appropriate first action?

  1. Consult with the patient's primary care physician regarding risks and possible medication holiday
  2. Extract all teeth as planned without modification
  3. Discontinue the bisphosphonate for 2 months then proceed with extractions
  4. Refuse to extract any teeth
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Correct answer: A. Consult with the patient's primary care physician regarding risks and possible medication holiday

Oral bisphosphonates (e.g., alendronate, risedronate) are associated with medication-related osteonecrosis of the jaw (MRONJ), a potentially serious complication following invasive dental procedures such as extractions. The risk increases with duration of use (>3 years), concurrent corticosteroid use, and patient systemic factors. Before proceeding with full-mouth extractions, the dentist must consult with the prescribing physician to assess the risk-benefit ratio, discuss the possibility of a 'drug holiday' (temporary discontinuation), and evaluate whether the bisphosphonate is essential for osteoporosis management. Simply extracting all teeth without consultation is inappropriate. Unilaterally stopping the medication for 2 months without physician guidance is also inappropriate, as the drug has a long half-life in bone (years).

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