Medical Emergencies · single question
A patient is suspected of having Sjögren's syndrome. Which laboratory test is most appropriate to order?
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Correct answer: B. Anti-SSA (Ro) and Anti-SSB (La) antibodies (ANA panel)
- A. CBC may show anemia or leukopenia in some autoimmune conditions but is not the specific diagnostic test for Sjögren's.
- B. CORRECT. The hallmark serological markers for Sjögren's syndrome are anti-SSA (Ro) and anti-SSB (La) antibodies. These are included in an ANA (antinuclear antibody) panel. Anti-SSA in particular is highly associated with primary Sjögren's and is used for diagnosis per the 2016 ACR/EULAR classification criteria.
- C. Liver function tests are not the primary diagnostic test for Sjögren's syndrome, although some patients with Sjögren's may develop liver involvement.
- D. Prothrombin time assesses coagulation and is not used in the diagnosis of Sjögren's syndrome.
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