Pathology · single question
A patient has multiple odontogenic keratocysts (OKCs) and supernumerary teeth. Which systemic condition are they at risk for?
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Correct answer: B. Basal cell carcinoma (Gorlin-Goltz syndrome / nevoid BCC syndrome)
- A. Hyperthyroidism has no association with multiple OKCs.
- B. Multiple OKCs + supernumerary teeth + skeletal anomalies + calcified falx cerebri + skin lesions = Gorlin-Goltz syndrome (nevoid basal cell carcinoma syndrome). PTCH1 gene mutation. These patients develop multiple BCCs of the skin.
- C. Hyperparathyroidism causes brown tumors (giant cell lesions) in bone, not OKCs.
- D. Scleroderma affects connective tissue systemically; not linked to OKCs.