Medical Emergencies · single question

A patient develops immediate (anaphylactic) allergic angioedema. What is the first-line medication?

  1. Diphenhydramine 50 mg IM
  2. Epinephrine 1:1,000 IM
  3. Epinephrine 1:10,000 IV
  4. Hydrocortisone IV
Show answer and explanation

Correct answer: B. Epinephrine 1:1,000 IM

  • A. Antihistamines are adjuncts; they are too slow for life-threatening airway angioedema.
  • B. Correct. Epinephrine 1:1,000 given IM is first-line for anaphylaxis/angioedema with airway involvement.
  • C. 1:10,000 IV is reserved for cardiac arrest, not initial anaphylaxis management.
  • D. Corticosteroids help prevent late-phase reactions but are not the first-line acute agent.

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