Pathology · single question

A lesion is biopsied, and the biopsy report diagnoses it as a brown tumor. This lesion is most similar to which of the following?

  1. Periapical cemento-osseous dysplasia
  2. Fibrous dysplasia
  3. Squamous cell carcinoma
  4. Central giant cell granuloma
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Correct answer: D. Central giant cell granuloma

A brown tumor is a bony lesion associated with hyperparathyroidism. It is histologically and radiographically similar to a central giant cell granuloma (CGCG), as both show multinucleated giant cells and vascular stroma. Periapical cemento-osseous dysplasia involves periapical bone but lacks giant cells. Fibrous dysplasia causes bone expansion with a "ground-glass" appearance but lacks the histology of a brown tumor. Squamous cell carcinoma is a malignancy with different histological characteristics.

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