A female patient presents with a well-defined unilocular radiolucency in the posterior maxilla. The MOST likely diagnosis is:

Correct answer: D. Adenomatoid odontogenic tumor (AOT)

• A. Central giant cell granuloma presents as a multilocular lesion, more common in the anterior mandible in younger patients.
• B. Ameloblastoma most commonly appears as a multilocular 'soap bubble' radiolucency in the posterior mandible; it is less common as a unilocular lesion in the maxilla.
• C. OKC most commonly occurs in the posterior mandible and has a tendency for recurrence; while it can be unilocular, it is more aggressive and less strictly female-predominant.
• D. Correct. AOT is classically associated with a unilocular, well-defined radiolucency in the ANTERIOR maxilla of young females (often around an unerupted canine). Posterior maxilla in a female also fits AOT demographics.