A child with a documented penicillin allergy needs antibiotic treatment. Which of the following should NOT be administered without allergy evaluation?

Amoxicillin is a penicillin-class antibiotic and shares the same beta-lactam ring structure as penicillin, meaning it has significant cross-reactivity potential in patients with penicillin allergy. A patient with documented penicillin allergy should not receive amoxicillin without allergy evaluation. Alternatives for penicillin-allergic patients include clindamycin, azithromycin, or metronidazole (in combination), depending on the indication. Cephalosporins carry a lower cross-reactivity risk (1-4% for later-generation cephalosporins) but should still be used cautiously in patients with severe penicillin allergy (anaphylaxis). The original question options were inappropriate for this clinical scenario and have been corrected.