Pathology · single question

A biopsy shows separation of epithelial cells FROM the basement membrane (subepithelial cleavage). Referral to which specialist is MOST appropriate?

  1. Ophthalmologist
  2. Endocrinologist
  3. Hematologist
  4. Nephrologist
Show answer and explanation

Correct answer: A. Ophthalmologist

Subepithelial cleavage (separation of epithelium from the basement membrane) is the histopathological hallmark of Mucous Membrane Pemphigoid (MMP) — also called cicatricial pemphigoid. MMP critically affects the eyes in approximately 75% of cases, causing scarring conjunctivitis, symblepharon, and potentially blindness. Referral to an Ophthalmologist is essential to prevent irreversible ocular damage. MMP also affects oral mucosa, skin, genitalia, larynx, and esophagus.

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