Pathology · single question
A biopsy shows separation of epithelial cells FROM the basement membrane (subepithelial cleavage). Referral to which specialist is MOST appropriate?
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Correct answer: A. Ophthalmologist
Subepithelial cleavage (separation of epithelium from the basement membrane) is the histopathological hallmark of Mucous Membrane Pemphigoid (MMP) — also called cicatricial pemphigoid. MMP critically affects the eyes in approximately 75% of cases, causing scarring conjunctivitis, symblepharon, and potentially blindness. Referral to an Ophthalmologist is essential to prevent irreversible ocular damage. MMP also affects oral mucosa, skin, genitalia, larynx, and esophagus.