Pathology · single question
A 7-year-old child presents with bilateral, symmetric expansion of the jaws. Histology shows multinucleated giant cells within a fibrous stroma. What is the most likely diagnosis?
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Correct answer: C. Cherubism
Cherubism is a childhood, genetically determined condition causing bilateral, symmetric multilocular radiolucencies of the jaws with giant-cell-rich fibrous tissue on histology, fitting the bilateral pediatric presentation.Other options: OKC is typically unilocular/multilocular but not bilaterally symmetric in this pattern. Hyperparathyroidism (brown tumor) shows giant cells but is rare in young children and is systemic. Ameloblastoma is usually a solitary, locally aggressive lesion of older patients.Key exam takeaway: Bilateral, symmetric giant-cell jaw expansion in a young child = cherubism.