Pathology · single question

A 7-year-old child presents with bilateral, symmetric expansion of the jaws. Histology shows multinucleated giant cells within a fibrous stroma. What is the most likely diagnosis?

  1. Odontogenic keratocyst (OKC)
  2. Hyperparathyroidism (brown tumor)
  3. Cherubism
  4. Ameloblastoma
Show answer and explanation

Correct answer: C. Cherubism

Cherubism is a childhood, genetically determined condition causing bilateral, symmetric multilocular radiolucencies of the jaws with giant-cell-rich fibrous tissue on histology, fitting the bilateral pediatric presentation.Other options: OKC is typically unilocular/multilocular but not bilaterally symmetric in this pattern. Hyperparathyroidism (brown tumor) shows giant cells but is rare in young children and is systemic. Ameloblastoma is usually a solitary, locally aggressive lesion of older patients.Key exam takeaway: Bilateral, symmetric giant-cell jaw expansion in a young child = cherubism.

Practice Pathology questions Pathology study notes

More Pathology practice questions