Pharmacology · single question
A 35-year-old patient with RA takes Methotrexate and Humira (adalimumab). What blood test must be done before dental treatment?
Show answer and explanation
Correct answer: B. Creatinine clearance
- A. Incorrect. CBC monitors for MTX-induced bone marrow suppression, but the key test for dosing safety is renal function.
- B. Correct. Methotrexate is renally excreted and nephrotoxic at high doses. Creatinine clearance (eGFR) is required to assess kidney function before treatment, as impaired clearance leads to MTX toxicity.
- C. Incorrect. INR monitors warfarin anticoagulation. Neither MTX nor Humira is an anticoagulant.
- D. Incorrect. Platelet count may be affected by MTX-induced thrombocytopenia, but creatinine clearance is the primary required test for Methotrexate management.