Pathology · single question

A 30-year-old woman appears anorexic, BP 88/55, with bronze-colored skin and pigmented oral mucosal lesions, reporting weakness. Most likely diagnosis?

  1. Addison disease
  2. Cushing syndrome
  3. Graves disease
  4. Hypothyroidism
Show answer and explanation

Correct answer: A. Addison disease

  • A. Correct. Addison disease (primary adrenal insufficiency) produces weight loss, hypotension, weakness, and characteristic bronze skin and patchy oral mucosal hyperpigmentation from elevated ACTH/MSH activity.
  • B. Cushing syndrome causes weight GAIN, central obesity, and hypertension — the opposite picture.
  • C. Graves disease (hyperthyroidism) causes weight loss but with heat intolerance, tachycardia, and exophthalmos, not bronze pigmentation.
  • D. Hypothyroidism causes weight gain, cold intolerance, and fatigue, not hyperpigmentation.

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