Pathology · single question
A 30-year-old woman appears anorexic, BP 88/55, with bronze-colored skin and pigmented oral mucosal lesions, reporting weakness. Most likely diagnosis?
Show answer and explanation
Correct answer: A. Addison disease
- A. Correct. Addison disease (primary adrenal insufficiency) produces weight loss, hypotension, weakness, and characteristic bronze skin and patchy oral mucosal hyperpigmentation from elevated ACTH/MSH activity.
- B. Cushing syndrome causes weight GAIN, central obesity, and hypertension — the opposite picture.
- C. Graves disease (hyperthyroidism) causes weight loss but with heat intolerance, tachycardia, and exophthalmos, not bronze pigmentation.
- D. Hypothyroidism causes weight gain, cold intolerance, and fatigue, not hyperpigmentation.