A 3-year-old patient presents with complete anodontia, dry and wrinkled skin. The most likely diagnosis is:

Correct answer: D. Ectodermal dysplasia

• A. Pierre Robin syndrome features micrognathia, cleft palate, and tongue displacement — not skin changes or anodontia.
• B. Regional odontodysplasia causes localized missing teeth with 'ghost' appearance, not complete anodontia with skin changes.
• C. Cherubism is a familial condition causing bilateral jaw swelling from fibrous tissue — it does not cause complete anodontia or skin changes.
• D. Correct. Ectodermal dysplasia is characterized by hypohidrosis (inability to sweat), hypotrichosis (sparse hair), hypodontia or anodontia, and characteristic skin findings. The combination of complete anodontia with dry, wrinkled skin is classic.