Pathology · patient case with 5 questions
Sjögren Syndrome and Blood Pressure Screening
demo: 56-year-old female
chief: “My mouth and eyes are constantly dry.”
history: Rheumatoid arthritis. Positive anti-SSA (Ro) and anti-SSB (La) antibodies.
meds: Hydroxychloroquine
findings: Blood pressure 145/92 mmHg on two readings. Dry, atrophic oral mucosa with a lobulated tongue, generalized gingival recession, marginal gingivitis, and rampant cervical caries. Bilateral parotid enlargement. Extensive interproximal staining.
Question 1
Which finding would you NOT expect in this patient?
Show answer and explanation
Correct answer: C. Multiple oral ulcerations
- A. Recession follows from the associated periodontal disease and mucosal atrophy.
- B. Gingivitis is common because reduced salivary flow impairs plaque clearance and buffering.
- C. Correct — this is the exception. Sjögren syndrome causes dryness, atrophy, and secondary infection; frank ulceration is not a characteristic feature. Recurrent oral ulcers would point toward Behçet disease or an autoimmune blistering disorder instead.
- D. Xerostomia is the cardinal oral feature, arising from lymphocytic destruction of the salivary parenchyma.
Question 2
Which antibody profile supports the diagnosis?
Show answer and explanation
Correct answer: B. Anti-SSA (Ro) and anti-SSB (La)
- A. Anti-desmoglein 3 antibodies are directed against desmosomes in pemphigus vulgaris.
- B. Correct. Anti-SSA/Ro and anti-SSB/La are the serologic markers of Sjögren syndrome, alongside labial minor salivary gland biopsy showing focal lymphocytic sialadenitis.
- C. Anti-CCP is specific for rheumatoid arthritis; it may coexist here but does not establish Sjögren syndrome.
- D. Anti-dsDNA is highly specific for systemic lupus erythematosus.
Question 3
Each of the following can cause interproximal staining EXCEPT:
Show answer and explanation
Correct answer: C. Tetracycline
- A. Chlorhexidine is a well-recognized cause of extrinsic brown staining, worst in interproximal and stagnation areas.
- B. Chromogenic bacteria produce black or green extrinsic stain, particularly along the gingival margin and interproximally.
- C. Correct — this is the exception. Tetracycline produces intrinsic discoloration by chelating with calcium during tooth development, giving banded grey-brown staining through the whole tooth — not surface interproximal stain.
- D. Iron supplements produce black extrinsic staining on tooth surfaces.
Question 4
Using the 2017 ACC/AHA thresholds, this patient's blood pressure of 145/92 mmHg is classified as:
Show answer and explanation
Correct answer: D. Stage 2 hypertension
- A. Hypertensive crisis is above 180/120 mmHg and requires urgent medical attention.
- B. Stage 1 is 130–139 systolic or 80–89 diastolic. Under the older JNC 7 scheme this reading would have been Stage 1, which is the source of the confusion on this item.
- C. Elevated blood pressure is 120–129 systolic with diastolic under 80.
- D. Correct. Under the 2017 ACC/AHA classification, Stage 2 begins at 140/90 mmHg, so 145/92 falls into Stage 2. Routine dental care may proceed with monitoring and medical referral for management.
Note: Know both frameworks. JNC 7 called 140–159/90–99 Stage 1; the 2017 ACC/AHA guideline lowered the thresholds so that the same reading becomes Stage 2. The recall answer follows ACC/AHA.
Question 5
For a patient with an asymptomatic blood pressure of 175/100 mmHg, the appropriate action is:
Show answer and explanation
Correct answer: A. Refer to a physician for evaluation while deferring elective care
- A. Correct. An asymptomatic reading in this range warrants medical referral and deferral of elective treatment; urgent care may proceed with monitoring and stress reduction.
- B. Ignoring a reading this high misses an opportunity to intervene in a modifiable cardiovascular risk.
- C. EMS activation is reserved for hypertensive crisis with end-organ symptoms — chest pain, visual change, neurologic deficit, or severe headache.
- D. Dentists do not initiate antihypertensive therapy; that is the physician's role.