Pathology · patient case with 5 questions

Sjögren Syndrome and Blood Pressure Screening

demo: 56-year-old female

chief: “My mouth and eyes are constantly dry.”

history: Rheumatoid arthritis. Positive anti-SSA (Ro) and anti-SSB (La) antibodies.

meds: Hydroxychloroquine

findings: Blood pressure 145/92 mmHg on two readings. Dry, atrophic oral mucosa with a lobulated tongue, generalized gingival recession, marginal gingivitis, and rampant cervical caries. Bilateral parotid enlargement. Extensive interproximal staining.

Question 1

Which finding would you NOT expect in this patient?

  1. Gingival recession
  2. Gingivitis
  3. Multiple oral ulcerations
  4. Xerostomia
Show answer and explanation

Correct answer: C. Multiple oral ulcerations

  • A. Recession follows from the associated periodontal disease and mucosal atrophy.
  • B. Gingivitis is common because reduced salivary flow impairs plaque clearance and buffering.
  • C. Correct — this is the exception. Sjögren syndrome causes dryness, atrophy, and secondary infection; frank ulceration is not a characteristic feature. Recurrent oral ulcers would point toward Behçet disease or an autoimmune blistering disorder instead.
  • D. Xerostomia is the cardinal oral feature, arising from lymphocytic destruction of the salivary parenchyma.

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Question 2

Which antibody profile supports the diagnosis?

  1. Anti-desmoglein 3
  2. Anti-SSA (Ro) and anti-SSB (La)
  3. Anti-cyclic citrullinated peptide alone
  4. Anti-double-stranded DNA
Show answer and explanation

Correct answer: B. Anti-SSA (Ro) and anti-SSB (La)

  • A. Anti-desmoglein 3 antibodies are directed against desmosomes in pemphigus vulgaris.
  • B. Correct. Anti-SSA/Ro and anti-SSB/La are the serologic markers of Sjögren syndrome, alongside labial minor salivary gland biopsy showing focal lymphocytic sialadenitis.
  • C. Anti-CCP is specific for rheumatoid arthritis; it may coexist here but does not establish Sjögren syndrome.
  • D. Anti-dsDNA is highly specific for systemic lupus erythematosus.

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Question 3

Each of the following can cause interproximal staining EXCEPT:

  1. Chlorhexidine rinse
  2. Chromogenic bacteria
  3. Tetracycline
  4. Iron supplements
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Correct answer: C. Tetracycline

  • A. Chlorhexidine is a well-recognized cause of extrinsic brown staining, worst in interproximal and stagnation areas.
  • B. Chromogenic bacteria produce black or green extrinsic stain, particularly along the gingival margin and interproximally.
  • C. Correct — this is the exception. Tetracycline produces intrinsic discoloration by chelating with calcium during tooth development, giving banded grey-brown staining through the whole tooth — not surface interproximal stain.
  • D. Iron supplements produce black extrinsic staining on tooth surfaces.

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Question 4

Using the 2017 ACC/AHA thresholds, this patient's blood pressure of 145/92 mmHg is classified as:

  1. Hypertensive crisis
  2. Stage 1 hypertension
  3. Elevated blood pressure
  4. Stage 2 hypertension
Show answer and explanation

Correct answer: D. Stage 2 hypertension

  • A. Hypertensive crisis is above 180/120 mmHg and requires urgent medical attention.
  • B. Stage 1 is 130–139 systolic or 80–89 diastolic. Under the older JNC 7 scheme this reading would have been Stage 1, which is the source of the confusion on this item.
  • C. Elevated blood pressure is 120–129 systolic with diastolic under 80.
  • D. Correct. Under the 2017 ACC/AHA classification, Stage 2 begins at 140/90 mmHg, so 145/92 falls into Stage 2. Routine dental care may proceed with monitoring and medical referral for management.

Note: Know both frameworks. JNC 7 called 140–159/90–99 Stage 1; the 2017 ACC/AHA guideline lowered the thresholds so that the same reading becomes Stage 2. The recall answer follows ACC/AHA.

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Question 5

For a patient with an asymptomatic blood pressure of 175/100 mmHg, the appropriate action is:

  1. Refer to a physician for evaluation while deferring elective care
  2. Proceed with all planned treatment without comment
  3. Call emergency medical services immediately
  4. Administer a sublingual antihypertensive in the dental office
Show answer and explanation

Correct answer: A. Refer to a physician for evaluation while deferring elective care

  • A. Correct. An asymptomatic reading in this range warrants medical referral and deferral of elective treatment; urgent care may proceed with monitoring and stress reduction.
  • B. Ignoring a reading this high misses an opportunity to intervene in a modifiable cardiovascular risk.
  • C. EMS activation is reserved for hypertensive crisis with end-organ symptoms — chest pain, visual change, neurologic deficit, or severe headache.
  • D. Dentists do not initiate antihypertensive therapy; that is the physician's role.

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