Biostatistics & Research · patient case with 3 questions
Evidence, vital signs and dental age
Scenario: Three items in research methods, medicine and growth.
Question 1
Which study design provides the highest level of evidence among those listed?
Show answer and explanation
Correct answer: C. Randomised controlled trial
- A. A case series simply describes a group of patients with no comparison group at all — near the bottom of the hierarchy.
- B. A cohort study follows exposed and unexposed groups forward and yields relative risk and incidence, but without randomisation confounding remains.
- C. Correct. Randomisation distributes known and unknown confounders evenly between groups, so the RCT gives the strongest causal inference of the designs listed.
- D. Case-control studies work backward from outcome to exposure. They are efficient for rare diseases but give odds ratios and are prone to recall bias.
Note: When a systematic review or meta-analysis appears among the options, it outranks the individual RCT. Here it was not offered.
Question 2
A blood pressure of 132/85 mmHg falls into which category?
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Correct answer: D. Stage 1 hypertension
- A. Hypertensive crisis is above 180 systolic or above 120 diastolic and calls for immediate medical attention.
- B. Elevated blood pressure requires systolic 120-129 AND diastolic below 80. A diastolic of 85 rules that out, and 132 systolic is above the range regardless.
- C. Stage 2 begins at 140 systolic or 90 diastolic.
- D. Correct. Under the 2017 ACC/AHA guideline, stage 1 hypertension is a systolic of 130-139 OR a diastolic of 80-89. This reading meets both criteria.
Note: That is incorrect. The reference table written in the margin of the same file actually contradicts the marked answer — 132/85 is stage 1 by both the systolic and the diastolic criterion. Worth correcting in the group notes.
Question 3
A 5-year-old already has erupted permanent mandibular incisors. Which statement about the chronological age is correct?
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Correct answer: A. The chronological age is behind the dental age
- A. Correct. Permanent mandibular incisors normally erupt around 6-7 years. Eruption at 5 means development has run ahead of the calendar, so dental age exceeds chronological age — the child's chronological age lags behind.
- B. Eruption timing is one of the standard methods of estimating dental age, alongside calcification staging, which is actually the more reliable of the two.
- C. This reverses the relationship. If the calendar were ahead of development, the teeth would be late, not early.
- D. They do not match here; that is the whole point of the item.
Note: ⚑ Read this stem carefully — the wording asks about the chronological age relative to the dental age, which inverts the intuitive answer. Several group members reported keying it the other way.