Pathology · patient case with 2 questions

Case: lethargy, low blood pressure and bronze skin

Scenario: A female patient is markedly lethargic. Her blood pressure is 80/60 and her skin shows a diffuse bronze pigmentation.

Question 1

What is the diagnosis?

  1. Haemochromatosis
  2. Cushing syndrome
  3. Hyperthyroidism
  4. Addison disease
Show answer and explanation

Correct answer: D. Addison disease

  • A. Haemochromatosis does bronze the skin through iron deposition, but it presents with diabetes and cirrhosis, not hypotension and adrenal collapse.
  • B. Cushing syndrome is cortisol excess — moon face, buffalo hump, central obesity and hypertension, the opposite haemodynamic picture.
  • C. Hyperthyroidism produces heat intolerance, weight loss, tremor and tachycardia, with warm moist skin rather than bronze pigmentation.
  • D. Correct. Primary adrenal insufficiency lowers cortisol; the pituitary compensates with more ACTH, and the melanocyte-stimulating fragment of that molecule bronzes the skin and mucosa. Hypotension, fatigue and salt craving complete the picture.

Permanent page for this question

Question 2

What is the best management for this patient?

  1. Prescribe fludrocortisone and review in one week
  2. Prescribe a course of corticosteroids yourself
  3. Proceed with elective dental treatment and monitor vital signs
  4. Refer to a physician for diagnosis and medical management
Show answer and explanation

Correct answer: D. Refer to a physician for diagnosis and medical management

  • A. Fludrocortisone is a mineralocorticoid used in confirmed adrenal insufficiency, again a physician's prescription after diagnosis.
  • B. Steroid replacement is a physician's decision requiring biochemical confirmation and titration. Starting steroids blindly can mask the diagnosis and cause harm.
  • C. Proceeding with elective treatment in an unstabilised patient risks precipitating an adrenal crisis — hypotension, collapse and shock.
  • D. Correct. This is an undiagnosed systemic endocrine disorder. It needs medical workup and stabilisation before any elective dental care; the dentist's role is timely referral.

Note: Once diagnosed and stabilised, the concern shifts to adrenal crisis under stress. Discuss any need for supplemental steroid cover with the physician rather than assuming it.

Permanent page for this question

Practice patient cases Pathology study notes