Pathology · patient case with 2 questions
Case: lethargy, low blood pressure and bronze skin
Scenario: A female patient is markedly lethargic. Her blood pressure is 80/60 and her skin shows a diffuse bronze pigmentation.
Question 1
What is the diagnosis?
Show answer and explanation
Correct answer: D. Addison disease
- A. Haemochromatosis does bronze the skin through iron deposition, but it presents with diabetes and cirrhosis, not hypotension and adrenal collapse.
- B. Cushing syndrome is cortisol excess — moon face, buffalo hump, central obesity and hypertension, the opposite haemodynamic picture.
- C. Hyperthyroidism produces heat intolerance, weight loss, tremor and tachycardia, with warm moist skin rather than bronze pigmentation.
- D. Correct. Primary adrenal insufficiency lowers cortisol; the pituitary compensates with more ACTH, and the melanocyte-stimulating fragment of that molecule bronzes the skin and mucosa. Hypotension, fatigue and salt craving complete the picture.
Question 2
What is the best management for this patient?
Show answer and explanation
Correct answer: D. Refer to a physician for diagnosis and medical management
- A. Fludrocortisone is a mineralocorticoid used in confirmed adrenal insufficiency, again a physician's prescription after diagnosis.
- B. Steroid replacement is a physician's decision requiring biochemical confirmation and titration. Starting steroids blindly can mask the diagnosis and cause harm.
- C. Proceeding with elective treatment in an unstabilised patient risks precipitating an adrenal crisis — hypotension, collapse and shock.
- D. Correct. This is an undiagnosed systemic endocrine disorder. It needs medical workup and stabilisation before any elective dental care; the dentist's role is timely referral.
Note: Once diagnosed and stabilised, the concern shifts to adrenal crisis under stress. Discuss any need for supplemental steroid cover with the physician rather than assuming it.